Characterization of Nucleic Acids by Nanopore Analysis
Accounts of Chemical Research2002Vol. 35(10), pp. 817–825
Citations Over TimeTop 1% of 2002 papers
Abstract
Single-stranded DNA and RNA molecules in solution can be driven through a nanoscopic pore by an applied electric field. As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information about length, composition, structure, and dynamic motion of the molecule can be deduced from modulations of the current blockade.
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