Evolution of Dithiane-Based Strategies for the Construction of Architecturally Complex Natural Products
Accounts of Chemical Research2004Vol. 37(6), pp. 365–377
Citations Over TimeTop 10% of 2004 papers
Abstract
Umpolung-based strategies play a significant role in organic synthesis. Particularly important are 1,3-dithiane linchpins, which serve as convenient acyl anion equivalents. The general synthetic accessibility and impressive reactivity of 1,3-dithianes have thus led to widespread application. Since the late 1970s, dithianes have featured prominently in our program directed toward the synthesis of complex natural and unnatural products, both for effective union of advanced fragments and for multicomponent linchpin couplings. In this Account, we present the evolution of dithiane chemistry in our laboratory.
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