Linker-Mediated Modulation of the Chemiluminescent Signal from N10-(3-Sulfopropyl)-N-sulfonylacridinium-9-carboxamide Tracers
Bioconjugate Chemistry2000Vol. 11(5), pp. 714–724
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Maciej Adamczyk, Yon-Yih Chen, Jeffrey R. Fishpaugh, Phillip G. Mattingly, You Pan, Kevin Shreder, Zhiguang Yu
Abstract
Four chemiluminescent N-sulfonylacridinium-9-carboxamide active esters (17-20) were prepared from the corresponding acids and coupled to both of the aminated phenobarbital (13) and N-(6-aminohexyl)phenytoin (16) haptens. The level of signal produced by chemiluminescent N-sulfonylacridinium-9-carboxamide phenobarbital and phenytoin tracers in a solid-phase immunoassay format was found to be modulated by at least 20-fold by the judicious choice of the reactive acridinium-hapten linking group.
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