Facile Synthesis of Raman Active Phospholipid Gold Nanoparticles
Bioconjugate Chemistry2010Vol. 21(12), pp. 2178–2182
Citations Over TimeTop 11% of 2010 papers
Abstract
Gold nanoparticle-based surface-enhanced Raman scattering (SERS) probes have shown promise for disease detection and diagnosis. To improve their structural and functional stability for in vivo applications, we synthesized a colloidal SERS gold nanoparticle that encapsulates Raman molecules adsorbed on 60 nm gold with a nonthiol phospholipid coating. Transmission electron microscopy and Raman and UV spectroscopy validated its reproducibility and stability. This novel lipid-based SERS probe provides a viable alternative to the PEGylation and silica coating strategies.
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