Porphyrin–Lipid Stabilized Gold Nanoparticles for Surface Enhanced Raman Scattering Based Imaging
Bioconjugate Chemistry2012Vol. 23(9), pp. 1726–1730
Citations Over TimeTop 10% of 2012 papers
Natalie C. M. Tam, Patrick Z. McVeigh, Thomas D. MacDonald, Arash Farhadi, Brian C. Wilson, Gang Zheng
Abstract
A porphyrin-phospholipid conjugate with quenched fluorescence was utilized to serve as both the Raman dye and a stabilizing, biocompatible surface coating agent on gold nanoparticles. Through simple synthesis and validation with spectroscopy and confocal microscopy, we show that this porphyrin-lipid stabilized AuNP is a novel SERS probe capable of cellular imaging. To date, this is the first use of porphyrin as a Raman reporter molecule for SERS based imaging.
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