Chemical Engineering of Mesenchymal Stem Cells to Induce a Cell Rolling Response
Bioconjugate Chemistry2008Vol. 19(11), pp. 2105–2109
Citations Over TimeTop 10% of 2008 papers
Debanjan Sarkar, Praveen Kumar Vemula, Grace Sock Leng Teo, Dawn P. Spelke, Rohit Karnik, Le Y. Wee, Jeffrey M. Karp
Abstract
Covalently conjugated sialyl Lewis X (SLeX) on the mesenchymal stem cell (MSC) surface through a biotin-streptavidin bridge imparts leukocyte-like rolling characteristics without altering the cell phenotype and the multilineage differentiation potential. We demonstrate that the conjugation of SLeX on the MSC surface is stable, versatile, and induces a robust rolling response on P-selectin coated substrates. These results indicate the potential to increase the targeting efficiency of any cell type to specific tissue.
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