Peptide−Oligonucleotide Phosphorothioate Conjugates with Membrane Translocation and Nuclear Localization Properties
Bioconjugate Chemistry1999Vol. 10(4), pp. 598–606
Citations Over TimeTop 12% of 1999 papers
Maxim Antopolsky, Elena Azhayeva, Unni Tengvall, Seppo Auriola, Ilpo Jääskeläinen, Seppo Rönkkö, Paavo Honkakoski, Arto Urtti, Harri Lönnberg, Alex Azhayev
Abstract
Eighteen peptide-oligonucleotide phosphorothioate conjugates were prepared in good yield and thoroughly characterized with electrospray ionization mass spectra. When applied to the living cells, conjugates exhibiting membrane translocation and nuclear localization properties displayed efficient intracellular penetration but failed to show any serious antisense effect. Studies on the intracellular distribution of the fluorescein-labeled conjugates revealed their trapping in endosomes.
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