Mammaglobin Is Found in Breast Tissue as a Complex with BU101
Biochemistry2001Vol. 40(37), pp. 11048–11059
Citations Over TimeTop 17% of 2001 papers
Tracey Colpitts, Patricia Billing-Medel, Paula N. Friedman, Edward N. Granados, Mark A. Hayden, Steve J. Hodges, Nick Menhart, Lisa Roberts, John A. Russell, Stephen D. Stroupe
Abstract
The mammaglobin gene has been shown to be preferentially expressed in breast tissue. Few genes match its specificity. Mammaglobin has generated much interest, and studies are ongoing to develop diagnostic tests for breast cancer based on the detection of mammaglobin. While searching the Incyte Genomics Lifeseq database for tissue-specific markers, we observed a second secretoglobin, BU101, also known as lipophilin B. We report here that mammaglobin, in breast tissue, is found as a complex with BU101. The complex was isolated from breast cancer tissue and was characterized as the biologically relevant form of mammaglobin.
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