A Potent Novel Anti-HIV Protein from the Cultured Cyanobacterium Scytonema varium
Biochemistry2003Vol. 42(9), pp. 2578–2584
Citations Over TimeTop 10% of 2003 papers
Heidi R. Bokesch, Barry R. O’Keefe, Tawnya C. McKee, Lewis K. Pannell, Gregory M. L. Patterson, Roberta S. Gardella, Raymond C. Sowder, Jim A. Turpin, Karen Watson, Robert W. Buckheit, Michael R. Boyd
Abstract
A new anti-HIV protein, scytovirin, was isolated from aqueous extracts of the cultured cyanobacterium Scytonema varium. The protein displayed potent anticytopathic activity against laboratory strains and primary isolates of HIV-1 with EC50 values ranging from 0.3 to 22 nM. Scytovirin binds to viral coat proteins gp120, gp160, and gp41 but not to cellular receptor CD4 or other tested proteins. This unique protein consists of a single 95-amino acid chain with significant internal sequence duplication and 10 cysteines forming five intrachain disulfide bonds.
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