Rheology of Gastric Mucin Exhibits a pH-Dependent Sol−Gel Transition
Biomacromolecules2007Vol. 8(5), pp. 1580–1586
Citations Over TimeTop 10% of 2007 papers
Jonathan P. Celli, Bradley S. Turner, Nezam H. Afdhal, Randy H. Ewoldt, Gareth H. McKinley, Rama Bansil, Shyamsunder Erramilli
Abstract
Gastric mucin, a high molecular weight glycoprotein, is responsible for providing the gel-forming properties and protective function of the gastric mucus layer. Bulk rheology measurements in the linear viscoelastic regime show that gastric mucin undergoes a pH-dependent sol-gel transition from a viscoelastic solution at neutral pH to a soft viscoelastic gel in acidic conditions, with the transition occurring near pH 4. In addition to pH-dependent gelation behavior in this system, further rheological studies under nonlinear deformations reveal shear thinning and an apparent yield stress in this material which are also highly influenced by pH.
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