AmphiphilicN-Glycosyl-thiocarbamoyl Cyclodextrins: Synthesis, Self-Assembly, and Fluorimetry of Recognition byLens culinarisLectin
Biomacromolecules2007Vol. 8(6), pp. 1851–1857
Citations Over TimeTop 10% of 2007 papers
Simone McNicholas, Anna Rencurosi, Luigi Lay, Antonino Mazzaglia, Luisa Sturiale, Marta Pérez, Raphael Darcy
Abstract
Amphiphilic beta-cyclodextrins have been synthesized bearing hexylthio, dodecylthio, and hexadecylthio chains at the 6-positions and glycosylthiocarbamoyl-oligo(ethylene glycol) units at the 2-positions. The glycosyl residues (alpha-D-mannosyl and beta-L-fucosyl) are intended for cell-targeting. Self-assembly of these new amphiphilic glycosylated cyclodextrins in water to form vesicles was investigated by dynamic light scattering and transmission electron microscopy. Selective binding of the hexylthio assemblies to a protein receptor (Lens culinaris lectin) was confirmed by fluorescence spectroscopy.
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