Photo-Cross-Linkable Thermoresponsive Star Polymers Designed for Control of Cell-Surface Interactions
Citations Over TimeTop 10% of 2010 papers
Abstract
Star polymers with thermoresponsive arms, consisting of 2-(2-methoxyethoxy)ethyl methacrylate (MEO₂MA) and oligo(ethylene glycol) methacrylate with ~4 ethylene oxide units (OEOMA₃₀₀, M(n) = 300), were synthesized via atom transfer radical polymerization (ATRP). 25% of the arms contained benzophenone chain-end functionality at the star periphery. A mixture of linear poly(MEO₂MA-co-OEOMA₃₀₀)-Br macroinitiators without and with benzophenone end-group macroinitiators were (MI and Bzp-MI, respectively) cross-linked with ethylene glycol dimethacrylate to form star polymers. Formation of star polymers was monitored by GPC, and the presence of benzophenone functionality in the stars was confirmed by ¹H NMR. The UV-vis spectroscopy revealed that the star polymers exhibit the low critical solution temperature (LCST) at 27 °C, slightly lower than LCST of either MI or Bzp-MI. Commercially available tissue culture grade polystyrene surface was modified by depositing a thin film of functionalized stars and UV cross-linking (λ = 365 nm). The star polymers covalently attached onto surfaces allowed a control of cell shrinkage and attachment in response to temperature changes.
Related Papers
- → Applications of thermally reversible polymers and hydrogels in therapeutics and diagnostics(1987)741 cited
- → Tunable pH- and Temperature-Sensitive Copolymer Libraries by Reversible Addition−Fragmentation Chain Transfer Copolymerizations of Methacrylates(2007)326 cited
- → LCST polymers: Thermoresponsive nanostructured assemblies towards bioapplications(2020)200 cited
- → The use of thermoresponsive hydrogels for on-off release of molecules(1995)102 cited
- → Novel pH-tunable thermoresponsive polymers displaying lower and upper critical solution temperatures(2015)41 cited