Self-Adjuvanting Polymer–Peptide Conjugates As Therapeutic Vaccine Candidates against Cervical Cancer
Biomacromolecules2013Vol. 14(8), pp. 2798–2806
Citations Over TimeTop 10% of 2013 papers
Tzu-Yu Liu, Waleed M. Hussein, Zhongfan Jia, Zyta M. Ziora, Nigel A.J. McMillan, Michael J. Monteiro, István Tóth, Mariusz Skwarczyński
Abstract
Dendrimers are structurally well-defined, synthetic polymers with sizes and physicochemical properties often resembling those of biomacromolecules (e.g., proteins). As a result, they are promising candidates for peptide-based vaccine delivery platforms. Herein, we established a synthetic pathway to conjugate a human papillomavirus (HPV) E7 protein-derived peptide antigen to a star-polymer to create a macromolecular vaccine candidate to treat HPV-related cancers. These conjugates were able to reduce tumor growth and eradicate E7-expressing TC-1 tumors in mice after a single immunization, without the help of any external adjuvant.
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