Lectin-Tagged Fluorescent Polymeric Nanoparticles for Targeting of Sialic Acid on Living Cells
Biomacromolecules2014Vol. 15(6), pp. 2012–2018
Citations Over TimeTop 10% of 2014 papers
Abstract
In this study, we fabricated lectin-tagged fluorescent polymeric nanoparticles approximately 35 nm in diameter using biocompatible polymers conjugated with lectins for the purpose of detecting sialic acid on a living cell surface, which is one of the most important biomarkers for cancer diagnosis. Through cellular experiments, we successfully detected sialic acid overexpression on cancerous cells with high specificity. These fluorescent polymeric nanoparticles can be useful as a potential bioimaging probe for detecting diseased cells.
Related Papers
- → The specificity of the binding site of AchatininH, a sialic acid-binding lectin from Achatina fulica(1995)64 cited
- → Identification of 9-O-acetyl-N-acetylneuraminic acid on the surface of BALB/c mouse erythrocytes(1980)35 cited
- → An Improved Method for the Preparation of Sialic Acid or Acetylneuraminic Acid(1956)2 cited
- [Electrophoresis on polyacrylamide gel of human salivary proteins containing acetylneuraminic acid and sialic acid].(1970)