Identification of Direct Protein Targets of Small Molecules
ACS Chemical Biology2010Vol. 6(1), pp. 34–46
Citations Over TimeTop 1% of 2010 papers
Abstract
Small-molecule target identification is a vital and daunting task for the chemical biology community as well as for researchers interested in applying the power of chemical genetics to impact biology and medicine. To overcome this "target ID" bottleneck, new technologies are being developed that analyze protein-drug interactions, such as drug affinity responsive target stability (DARTS), which aims to discover the direct binding targets (and off targets) of small molecules on a proteome scale without requiring chemical modification of the compound. Here, we review the DARTS method, discuss why it works, and provide new perspectives for future development in this area.
Related Papers
- → Discovery of New Small Molecules and Targets Towards Angiogenesis Via Chemical Genomics Approach(2006)18 cited
- → 8 Chemical genetics(2004)4 cited
- → Novel Natural Products Open the Door of Chemical Biology and Medicinal Chemistry(2010)2 cited
- → Chemical Kinomics(2004)2 cited
- → Putting small molecules in the lead(2005)1 cited