Evidence for Age-Dependent in Vivo Conformational Rearrangement within Aβ Amyloid Deposits
ACS Chemical Biology2013Vol. 8(6), pp. 1128–1133
Citations Over TimeTop 10% of 2013 papers
Sofie Nyström, Katarzyna M. Psonka-Antonczyk, Pål Gunnar Ellingsen, Leif B. G. Johansson, Nina Kristine Reitan, Susann Handrick, Stefan Prokop, Frank L. Heppner, Bettina M. Wegenast‐Braun, Mathias Jucker, Mikaël Lindgren, Bjørn T. Stokke, Per Hammarström, K. Peter R. Nilsson
Abstract
Deposition of aggregated Aβ peptide in the brain is one of the major hallmarks of Alzheimer's disease. Using a combination of two structurally different, but related, hypersensitive fluorescent amyloid markers, LCOs, reporting on separate ultrastructural elements, we show that conformational rearrangement occurs within Aβ plaques of transgenic mouse models as the animals age. This important mechanistic insight should aid the design and evaluation of experiments currently using plaque load as readout.
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