Bacterial Histidine Kinases as Novel Antibacterial Drug Targets
ACS Chemical Biology2014Vol. 10(1), pp. 213–224
Citations Over TimeTop 10% of 2014 papers
E. Agnieszka, Nadya Velikova, María Teresa Pellicer Jordá, Peter van Baarlen, Alberto Marina, Jerry M. Wells
Abstract
Bacterial histidine kinases (HKs) are promising targets for novel antibacterials. Bacterial HKs are part of bacterial two-component systems (TCSs), the main signal transduction pathways in bacteria, regulating various processes including virulence, secretion systems and antibiotic resistance. In this review, we discuss the biological importance of TCSs and bacterial HKs for the discovery of novel antibacterials, as well as published TCS and HK inhibitors that can be used as a starting point for structure-based approaches to develop novel antibacterials.
Related Papers
- → Stoichiometry and perturbation studies of the LiaFSR system of Bacillus subtilis(2012)50 cited
- → Regulation of Virulence by Two-Component Systems in Pathogenic Burkholderia(2020)35 cited
- → The multi-step phosphorelay mechanism of unorthodox two-component systems in E. coli realizes ultrasensitivity to stimuli while maintaining robustness to noises(2006)56 cited
- → Proteolysis and multimerization regulate signaling along the two-component regulatory system AdeRS(2021)13 cited
- → Interaction Analysis of a Two-Component System Using Nanodiscs(2016)19 cited