A Genetically Encoded FRET Sensor for Intracellular Heme
ACS Chemical Biology2015Vol. 10(7), pp. 1610–1615
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Yanqun Song, Maiyun Yang, Seraphine V. Wegner, Jingyi Zhao, Rongfeng Zhu, Yun Wu, Chuan He, Peng R. Chen
Abstract
Heme plays pivotal roles in various cellular processes as well as in iron homeostasis in living systems. Here, we report a genetically encoded fluorescence resonance energy transfer (FRET) sensor for selective heme imaging by employing a pair of bacterial heme transfer chaperones as the sensory components. This heme-specific probe allows spatial-temporal visualization of intracellular heme distribution within living cells.
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