Illuminating the Chemistry of Life: Design, Synthesis, and Applications of “Caged” and Related Photoresponsive Compounds
Citations Over TimeTop 1% of 2009 papers
Abstract
Biological systems are characterized by a level of spatial and temporal organization that often lies beyond the grasp of present day methods. Light-modulated bioreagents, including analogs of low molecular weight compounds, peptides, proteins, and nucleic acids, represent a compelling strategy to probe, perturb, or sample biological phenomena with the requisite control to address many of these organizational complexities. Although this technology has created considerable excitement in the chemical community, its application to biological questions has been relatively limited. We describe the challenges associated with the design, synthesis, and use of light-responsive bioreagents; the scope and limitations associated with the instrumentation required for their application; and recent chemical and biological advances in this field.
Related Papers
- → Optimal grasping based on non-dimensionalized performance indices(2002)58 cited
- → Non-dimensionalized performance indices based optimal grasping for multi-fingered hands(2003)39 cited
- → Human Grasping Simulation(2013)
- → Contact Point Identification by Active Sensing in Enveloping Grasp.(1995)
- → 3619 Planning of Grasp/Non-Grasp Constraining of Objects by a Multifingered Robot Hand(2008)