Synthesis of a New Fluoro-Wang Resin for Solid-Phase Reaction Monitoring by 19F NMR Spectroscopy
Journal of Combinatorial Chemistry2001Vol. 3(2), pp. 177–180
Citations Over TimeTop 22% of 2001 papers
Joseph M. Salvino, Sharmila Patel, Mark D. Drew, Paul Krowlikowski, Edward Orton, N. Vassant Kumar, Thomas J. Caulfield, Richard Labaudinière
Abstract
A new fluoro-Wang resin is presented which facilitates solid-phase reaction monitoring using 19F NMR. The resin is easily synthesized and amenable to scale-up. The method described herein compliments single-bead FT-IR and 13C NMR techniques. This method allows monitoring of solid-phase reactions even if the resin bound intermediate is unstable to the cleavage conditions. In addition, this is a useful tool to study reaction kinetics on the solid phase.
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