2-Methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles: Versatile Starting Materials for the Synthesis of Libraries with Diverse Heterocyclic Scaffolds
Journal of Combinatorial Chemistry2005Vol. 7(3), pp. 436–448
Citations Over TimeTop 22% of 2005 papers
Blanca Martínez‐Teipel, Jordi Teixidó, Rosalía Pascual, Marta Mora, Josep Pujolà, Ted Fujimoto, José I. Borrell, Enrique L. Michelotti
Abstract
Heterocyclic demonstration libraries for agrochemical screening were prepared from the common intermediates 2-methoxy-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles (1), using standard solution-phase techniques. A total of 18 screening libraries were prepared in good to excellent yields. Several members of these libraries were active in the first level of agrochemical screening, especially in the fungicide screen.
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