Synthesis of Flavonoid Analogues as Scaffolds for Natural Product-Based Combinatorial Libraries

Citations Over TimeTop 19% of 2007 papers

Abstract

The design and synthesis of flavonoid analogues as combinatorial scaffolds is reported. Using commercially available materials, we synthesized chalcones with fluoro and carboxy groups. Nitration of these compounds generated highly functionalized flavonoid scaffolds with an o-fluoronitrobenzene template. Subsequent cyclizations of these chalcones resulted in the formation of several flavone and flavonone scaffolds. One of the flavonones was chosen as the scaffold to synthesize flavonoid derivatives on the solid phase. A series of flavonoid derivatives were obtained in high yields, which demonstrates that these highly functionalized scaffolds can be used in the synthesis of natural product-based combinatorial libraries for drug discovery.

Related Papers

• → Design and Synthesis of Natural Product Inspired Libraries Based on the Three-Dimensional (3D) Cedrane Scaffold: Toward the Exploration of 3D Biological Space(2018)30 cited
• → Synthesis and evaluation of paclitaxel C7 derivatives: Solution phase synthesis of combinatorial libraries(1998)23 cited
• → Solution-Phase Synthesis of Novel Linear Oxyamine Combinatorial Libraries with Antibacterial Activity(1998)11 cited
• Recent Advance in Solution - Phase Combinatorial Synthesis(2000)
• → Solid Phase Synthesis of 1,2,4-Triazinan-3-ones(2001)