One-Pot Synthesis of Quinoline-Based Tetracycles by a Tandem Three-Component Reaction
Journal of Combinatorial Chemistry2007Vol. 9(6), pp. 982–989
Citations Over TimeTop 14% of 2007 papers
Abstract
A practical one-pot synthetic strategy for the efficient synthesis of a range of structurally interesting and bioactive quinoline-based tetracycles has been developed. A key step in the synthesis is a tandem three-component reaction of heteroaromatic amine, methyl 2-formylbenzoate and (t)butyl isonitrile, followed by TFA-mediated lactamization via intramolecular aminolysis of an adjacent ester. Results related to a kinase-panel screening for several selected compounds are also discussed in this article.
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