Regiospecific Solid-Phase Strategy to N7-Substituted Purines and Its Application to 8-Azapurines and [i]-Condensed Purines
Journal of Combinatorial Chemistry2007Vol. 9(5), pp. 804–810
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Abstract
A highly regioselective and traceless solid-phase route to 1,7,8-trisubstituted purines has been developed. This methodology could be extended to the preparation of 8-azapurines and [i]-condensed purines. A representative set of 17 purines, azapurines, and [i]-condensed purines was synthesized. This paper also describes a mild method to prepare the p-benzyloxybenzylamine (BOBA) resin.
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