Efficient One-Pot Synthesis of Spirooxindole Derivatives Catalyzed byl-Proline in Aqueous Medium
Journal of Combinatorial Chemistry2010Vol. 12(2), pp. 231–237
Citations Over TimeTop 1% of 2010 papers
Abstract
An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile (cyanoacetic ester) and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported. This new protocol has the advantages of environmental friendliness, higher yields, shorter reaction times, low cost, and convenient operation.
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