Direct Design of Pharmaceutical Antisolvent Crystallization through Concentration Control
Crystal Growth & Design2006Vol. 6(4), pp. 892–898
Citations Over TimeTop 10% of 2006 papers
George Zhou, Mitsuko Fujiwara, Xing Yi Woo, Effendi Rusli, Hsien‐Hsin Tung, Cindy Starbuck, Omar Davidson, Zhihong Ge, Richard D. Braatz
Abstract
Recent advances in in situ measurement technology and automation of batch crystallizers have enabled the development of batch crystallization recipes in which the desired supersaturation profile is followed by feedback control. This paper describes a new approach for following supersaturation setpoints for antisolvent crystallizations that is easy to implement for the tried crystallization. Simulations and application to a proprietary drug compound demonstrate how this combination of automation and in process measurements enables the rapid development of batch crystallization processes in the pharmaceutical industry.
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