Solution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents
Crystal Growth & Design2014Vol. 14(8), pp. 3967–3974
Citations Over TimeTop 13% of 2014 papers
Abstract
The solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5–50 °C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.
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