Molecular Design Based on 3D-Pharmacophore. Application to 5-HT4 Receptor
Journal of Chemical Information and Computer Sciences2002Vol. 42(4), pp. 962–967
Citations Over Time
Ronan Bureau, Cyril Daveu, Stéphane Lemaître, François Dauphin, Henriette Landelle, Jean‐Charles Lancelot, Sylvain Rault
Abstract
A definition of a pharmacophore for the 5-HT4 antagonist was carried out by considering a three-dimensional model which correlates the chemical structures of series of antagonists with their biological affinities. A molecular design is described by analyzing the differences between two 3D serotonin pharmacophores. This successful structural modification demonstrates the efficiency of this approach to design new serotonin ligands.
Related Papers
- → Synthesis and Characterization of Photolabile Derivatives of Serotonin for Chemical Kinetic Investigations of the Serotonin 5-HT3 Receptor(2000)58 cited
- → Characterization of 5‐HT1A,B and 5‐HT2A,C Serotonin Receptor Binding(2001)5 cited
- → 5-HT<sub>2A</sub>, 5-HT<sub>1B/D</sub>, 5HT<sub>3</sub> and 5-HT<sub>7</sub> receptors as mediators of serotonin-induced direct contractile response of bovine airway smooth muscle(2021)3 cited
- → Evidence for serotonin (5HT) binding sites on murine lymphocytes(1987)21 cited
- → Serotonin (5-HT)-induced enhancement in the colonic motility is mediated through 5-HT1-like and 5-HT2 receptors in dogs(1995)