Molecular Design Based on 3D Pharmacophores. Applications to 5-HT7Receptors
Journal of Chemical Information and Computer Sciences2004Vol. 44(3), pp. 1148–1152
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Alban Lepailleur, Ronan Bureau, Stéphane Lemaître, François Dauphin, Jean‐Charles Lancelot, Vincent Contesse, Sébastien Lenglet, Catherine Delarue, Hubert Vaudry, Sylvain Rault
Abstract
A definition of a pharmacophore for the 5-HT7 antagonists was carried out by searching the common chemical features of selective antagonists from the literature. A molecular design is described by analyzing the differences between this new pharmacophore and three other 3D serotonin pharmacophores previously described. This comparison led to the synthesis of a new series of potent 5-HT7 antagonists.
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