Development of a Quantitative Structure−Activity Relationship Model for Inhibition of Gram-positive Bacterial Cell Growth by Biarylamides
Journal of Chemical Information and Computer Sciences2003Vol. 44(1), pp. 221–229
David T. Stanton, Prakash J. Madhav, Larry J. Wilson, Timothy W. Morris, Paul Hershberger, Christian N. Parker
Abstract
A set of compounds consisting of a new and diverse collection of biarylamides was examined using quantitative structure-activity relationship techniques for the purpose of developing a model to describe inhibition of gram-positive bacterial growth (minimum inhibition concentration). The model was sought in order to obtain insight for designing new molecules. A detailed analysis of the underlying structure-activity relationship helped provide insight concerning which structural features of the molecules modulated the activity of the compounds against gram-positive organisms.
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