Precise Engineering of Multifunctional PEGylated Polyester Nanoparticles for Cancer Cell Targeting and Imaging
Citations Over TimeTop 10% of 2014 papers
Abstract
Multifunctional poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA) nanoparticles for cancer cell targeting and imaging have been designed by a combination of ring-opening polymerization and “click” chemistry. Nanoparticles containing both a targeting ligand and a fluorescent probe were prepared by blending PLA-b-PEG–ligand, PLA-b-PEG–fluorescent probe, and PLA-b-PEG–OMe copolymers at the molar ratios necessary to achieve the desired surface ligand and fluorescent probe densities. This strategy has been illustrated by the preparation of a large library of a variety of nanoparticles, such as ligand-decorated nanoparticles (with biotin, folic acid or anisamide), fluorescent nanoparticles (UV–vis or near-infrared dyes), and multifunctional nanoparticles decorated with a targeting ligand and a fluorescent probe. Successful targeting was demonstrated by surface plasmon resonance and in vitro experiments on different cancer cell lines.
Related Papers
- → Peptide and protein PEGylation(2001)1,048 cited
- → Application of microchip CGE for the analysis of PEG‐modified recombinant human granulocyte‐colony stimulating factors(2010)16 cited
- → PEGylated Antibodies and DNA in Organic Media and Genetic PEGylation(2013)1 cited
- Gene silencing efficiency of siRNA-PEG conjugates : effect of PEGylation site and PEG molecular weight = PEGylation site와 PEG 분자량이 siRNA-PEG conjugate의 유전자 발현 억제에 미치는 영향에 관한 연구(2010)
- → Author Index for Volume 376, Number 1(2000)