Physiological Temperature Has a Crucial Role in Amyloid Beta in the Absence and Presence of Hydrophobic and Hydrophilic Nanoparticles
Citations Over TimeTop 11% of 2012 papers
Abstract
Amyloid beta fibrillation can lead to major disorder of neurons processes and is associated with several neuronal diseases (e.g., Alzheimer's disease). We report here an importance of slight temperature changes, in the physiological range (35-42 °C), on the amyloid fibrillation process in the presence and absence of hydrophilic (silica) and hydrophobic (polystyrene) nanoparticles (NPs). The results highlight the fact that slight increases in temperature can induce inhibitory and acceleratory effects of hydrophobic and hydrophilic NPs on the fibrillation process, respectively. Using further in vivo considerations, the outcomes of this study can be used for considerable modifications on the current diagnosis and treatment approaches in amyloid-involved diseases.
Related Papers
- Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease.(1998)
- → The beta APP717 Alzheimer mutation increases the percentage of plasma amyloid-beta protein ending at A beta 42(43)(1997)106 cited
- Differential effect of agents altering vesicular pH on the generation of amyloid beta-peptide derived from mutant or wild type beta-APP(1994)
- → ChemInform Abstract: REACTION OF BETA‐DIKETONES WITH TRIPHENYLPHOSPHINE DIHALIDES, A NEW, EFFICIENT SYNTHESIS OF CYCLIC BETA‐CHLORO‐, BETA‐BROMO‐ AND BETA‐IODO‐ALPHA,BETA‐UNSATURATED KETONES(1975)
- → ChemInform Abstract: BIS‐BETA‐CHLORAETHYLSULFIDE 3. MITT. SULFONE DER ALPHA‐CHLOR‐BETA‐(BETA‐CHLORAETHYLMERCAPTO)‐ UND BETA‐CHLOR‐ALPHA‐(BETA‐CHLORAETHYLMERCAPTO)‐ISOBUTTERSAEURE(1972)