The First CNS-Active Carborane: A Novel P2X7 Receptor Antagonist with Antidepressant Activity
ACS Chemical Neuroscience2014Vol. 5(5), pp. 335–339
Citations Over TimeTop 1% of 2014 papers
Shane M. Wilkinson, Hendra Gunosewoyo, Melissa L. Barron, Aurélie A. Boucher, Michelle N. McDonnell, Peter Turner, Daniel E. Morrison, Maxwell R. Bennett, Iain S. McGregor, Louis M. Rendina, Michael Kassiou
Abstract
Relative to other polycyclic frameworks (1-3), a carborane cage (4 and Cs·5) exerts a significant biological effect as an inhibitor of the purinergic P2X7 receptor (P2X7R) which allows one to target depression in vivo and thus demonstrate, for the first time, that a carborane has the capacity to modify CNS activity.
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