High-Throughput Screening of Small Molecule Libraries using SAMDI Mass Spectrometry

Citations Over TimeTop 12% of 2011 papers

Abstract

High-throughput screening is a common strategy used to identify compounds that modulate biochemical activities, but many approaches depend on cumbersome fluorescent reporters or antibodies and often produce false-positive hits. The development of "label-free" assays addresses many of these limitations, but current approaches still lack the throughput needed for applications in drug discovery. This paper describes a high-throughput, label-free assay that combines self-assembled monolayers with mass spectrometry, in a technique called SAMDI, as a tool for screening libraries of 100,000 compounds in one day. This method is fast, has high discrimination, and is amenable to a broad range of chemical and biological applications.

Related Papers

• → Antibody-enabled small-molecule drug discovery(2012)79 cited
• → ARQiv-HTS, a versatile whole-organism screening platform enabling in vivo drug discovery at high-throughput rates(2016)50 cited
• → High-Throughput and In Silico Screening in Drug Discovery(2017)10 cited
• Status of High Throughput Drug Screening and the Application of Optical-coded Technology in it(2003)
• Designing and implementation of high throughput screening for drugs(2005)