Venting-while-Heating Microwave-Assisted Synthesis of 3-Arylthioindoles
ACS Combinatorial Science2012Vol. 14(4), pp. 258–262
Citations Over TimeTop 10% of 2012 papers
Abstract
We report the first example of venting-while-heating microwave-assisted synthesis of a small library of 3-arylthioindoles. Compounds were prepared in excellent isolated yields (90-98%) within 4 min in a closed vessel by treating indoles with disulfides in the presence of sodium hydride in anhydrous N,N-dimethylformamide. The method was not affected by electron-donating and -withdrawing substituents both on 3-arylthio moiety and at 2- and 5-positions of the indole nucleus.
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