High-Throughput Production and Structural Characterization of Libraries of Self-Assembly Lipidic Cubic Phase Materials
ACS Combinatorial Science2012Vol. 14(4), pp. 247–252
Citations Over TimeTop 12% of 2012 papers
Connie Darmanin, Charlotte E. Conn, Janet Newman, Xavier Mulet, Shane A. Seabrook, Yi-Lynn Liang, Adrian Hawley, Nigel Kirby, Joseph Varghese, Calum J. Drummond
Abstract
A protocol is presented for the high-throughput (HT) production of lyotropic liquid crystalline phases from libraries of lipids and lipid mixtures using standard liquid dispensing robotics, implementing methods that circumvent the problems traditionally associated with handling the highly viscous cubic phase. In addition, the ability to structurally characterize lipidic phases and assess functionality for membrane proteins contained within cubic phases, in a HT manner, is demonstrated. The techniques are combined and exemplified using the application of membrane protein crystallization within lipidic cubic phases.
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