Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms

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Abstract

ADVERTISEMENT RETURN TO ISSUEPREVarticleAssembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and MechanismsMichael A. FischbachMichael A. FischbachDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115 and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 More by Michael A. Fischbach and Christopher T. Walsh*Christopher T. WalshDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115 and Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 To whom correspondence should be addressed: christopher_walsh@ hms.harvard.edu. More by Christopher T. WalshCite this: Chem. Rev. 2006, 106, 8, 3468–3496Publication Date (Web):July 19, 2006Publication History Published online19 July 2006Published inissue 1 August 2006https://pubs.acs.org/doi/10.1021/cr0503097https://doi.org/10.1021/cr0503097research-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views19042Altmetric-Citations1188LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Acyls,Condensation,Deformation,Monomers,Peptides and proteins Get e-Alerts

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