Intake of Iodine and Perchlorate and Excretion in Human Milk

Citations Over TimeTop 10% of 2008 papers

Abstract

Perchlorate, thiocyanate, and iodine excretion in urine and milk of 13 breastfeeding women was investigated and the results were interpreted by a model of parallel/competitive transport of these species bythe sodium iodide symporter. For each species i, we assumed physiological homeostasis, where i(T,in) equals the corresponding total excretion in urine and milk (i(e,u) + i(e,m)). The fraction of the total excretion that appeared in milk f(I,m) was measured and ranged from 0.394-0.781, 0.018-0.144, and 0.086-0.464 for perchlorate,thiocyanate, and iodine, respectively. The corresponding median values were 0.541, 0.053, and 0.177, respectively. The selectivity factors of perchlorate over iodide transport, and thiocyanate over iodide transport, defined as f(PC,m)/ f(I,m), and f(SCN,m)/ f(I,m), respectively, were 3.14 +/- 1.20 and 0.27 +/- 0.26 while PC(T,in), SCN(T,in), and I(T,in) among individuals varied 4.9, 5.0, and 8.4x, respectively. These transport selectivities are an order of magnitude lower than those indicated by in vitro studies, suggesting that the impact of both these anions on inhibiting iodide transport in milk may have been overestimated in the extant literature. On the other hand, our results showed that 12 of 13 infants did not have an adequate intake of iodine as defined by the Institute of Medicine and 9 out of 13 infants were likely ingesting perchlorate at a level exceeding the reference dose suggested bythe National Academy of Science panel.

Related Papers

• → Determination of iodide, iodate and organo-iodine in waters with a new total organic iodine measurement approach(2013)96 cited
• → Potentiometric association constant measurements of α, β or γ-cyclodextrin complexes involving iodide, tri-iodide or iodine species(1985)44 cited
• → Iodine or Iodide? A Laboratory Evaluation of the Content of Powdered Iodine Supplements(2017)2 cited
• → The Colorimetric Determination of Small Amounts of Iodide, with Special Reference to the Determination of Iodide in the Presence of Organically-Bound Iodine(1963)3 cited
• [Retroinhibition of thyroid iodide active transport in rats, after a long iodine deficient diet followed by a normal iodine diet].(1982)