Impacts of Competitive Inhibition, Parent Compound Formation and Partitioning Behavior on the Removal of Antibiotics in Municipal Wastewater Treatment

Citations Over TimeTop 10% of 2009 papers

Abstract

We present a process model that predicts the removal of the antibiotic micropollutants, sulfamethoxazole (SMX), tetracycline (TCY), and ciprofloxacin (CIP), in an activated sludge treatment system. A novel method was developed to solve the inverse problem of inferring process rate, sorption, and correction factor parameter values from batch experimental results obtained under aerobic and anoxic conditions. Instead of spiking the batch reactors with reference substances, measurements were made using the xenobiotic organic micropollutant content of preclarified municipal sewage. Parent compound formation and removal were observed, and the model developed using the simulation software West showed limited efficiency to describe the selected micropollutants profiles, when growth substrate removal occurs. The model structure was optimized by accounting for competitive inhibition by readily biodegradable substrates on the cometabolic micropollutant biotransformation processes. Our results suggest that, under anoxic conditions, hydrophobicity-independent mechanisms can significantly impact solid−liquid partitioning that our model takes into account by using the sorption coefficient as a lumped parameter. Forward dynamic simulations were carried out to evaluate the developed model and to confirm it for SMX using data obtained in a full-scale treatment plant. Evaluation of measured and simulation results suggest that, robust model prediction can be achieved by approximating the influent load of chemicals biodegrading via a given parent compound, e.g., human conjugates, as an antibiotic mass that is proportional to the parent compound load.

Related Papers

• → Modelling cometabolic biotransformation of organic micropollutants in nitrifying reactors(2014)77 cited
• → Oxygen Tolerance of Sulfate-Reducing Bacteria in Activated Sludge(2004)85 cited
• → Highly Efficient Transformation of Bisphenol S by Anaerobic Cometabolism in the Bioelectrochemical System(2019)7 cited
• → Verification of anoxic phosphate uptake as the main biochemical mechanism of the “dephanox” process(1997)11 cited
• → Modeling of Aerobic Wastewater Treatment Processes(2004)