A Platinum(IV) Complex Oxidizes Guanine to 8-Oxo-Guanine in DNA and RNA
Inorganic Chemistry2001Vol. 40(22), pp. 5481–5482
Citations Over Time
Abstract
A platinum(IV) complex with a high reduction potential, d,l-1,2-diaminocyclohexyltetrachloroplatinum(IV) (PtIV(dach)Cl4), oxidizes guanine in guanosine-5‘-monophosphate (GMP), 2‘-deoxyguanosine-5‘-monophosphate (dGMP), d(GG), and a double-stranded oligonucleotide to 8-oxo-guanine. To the best of our knowledge, this is the first report that provides unambiguous evidence of DNA oxidation by a PtIV complex. This oxidative damage may differentiate the anticancer activity of PtIV complexes from their PtII analogues.
Related Papers
- → Sonoelectrochemical studies of guanine and guanosine(1997)69 cited
- → Adsorption of guanine and guanosine at the pyrolytic graphite electrode(1971)69 cited
- → Mechanisms of Formation of Adducts from Reactions of Glycidaldehyde with 2‘-Deoxyguanosine and/or Guanosine(1996)38 cited
- → Intermediates in the browning reaction of triose reductone with guanine, guanosine or guanylic acid.(1979)2 cited
- → Intermediates in the Browning Reaction of Triose Reductone with Guanine, Guanosine or Guanylic Acid(1979)