[Gd-AAZTA]-: A New Structural Entry for an Improved Generation of MRI Contrast Agents
Inorganic Chemistry2004Vol. 43(24), pp. 7588–7590
Citations Over TimeTop 10% of 2004 papers
Silvio Aime, Luisella Calabi, Camilla Cavallotti, Eliana Gianolio, Giovanni B. Giovenzana, Pietro Losi, Alessandro Maiocchi, Giovanni Palmisano, Massimo Sisti
Abstract
An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex [Gd(AAZTA)]- shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents.
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