Synthesis of Zinc, Copper, Nickel, Cobalt, and Iron Complexes Using Tris(pyrazolyl)methane Sulfonate Ligands: A Structural Model for N,N,O Binding in Metalloenzymes
Citations Over TimeTop 10% of 2006 papers
Abstract
Ligands of intermediate steric bulk were designed to mimic metalloenzymes with histidine and carboxlyate binding sites. The reaction between tris(3-isopropylpyrazolyl)methane and butyllithium followed by SO3NMe3 in THF yielded the new ligand lithium tris(3-isopropylpyrazolyl)methane sulfonate (LiTpmsiPr). Various metal salts reacted with LiTpmsiPr to give the octahedral complexes M(TpmsiPr)2 (M = Zn, Cu, Ni, Co, Fe) in which each ligand has N,N,O binding to the metal. In the reaction between LiTpmsiPr and ZnCl2, in addition to the major product Zn(TpmsiPr)2, [LiTpmsiPrZnCl2].2THF was also formed as a minor product with a tetrahedral zinc atom coordinated to either N,N,Cl,Cl in the solid phase or N,N,N,Cl in acetonitrile solution. Although TpmsiPr is coordinatively flexible and can act as a bipodal or tripodal ligand, it appears to favor the formation of octahedral L2M complexes.
Related Papers
- → Quantification of the Steric Properties of 1,8-Naphthyridine-Based Ligands in Dinuclear Complexes(2022)13 cited
- → Escherichia coli gene that controls sensitivity to alkylating agents(1978)83 cited
- → An estimate of the steric bulk of the trimethyltin group.(1972)17 cited
- → Steric Effects. II. General Equations. Application to Cis- and Trans−2-Butene(1948)18 cited
- → Quantification of the Steric Properties of 1,8-Naphthyridine Based Ligands in Dinuclear Complexes(2022)