Studies on the Narciclasine Alkaloids: Total Synthesis of (+)-Narciclasine and (+)-Pancratistatin
Journal of the American Chemical Society2000Vol. 122(28), pp. 6624–6628
Citations Over TimeTop 10% of 2000 papers
Abstract
Enantioselective total syntheses of the antitumor alkaloids, (+)-narciclasine and (+)-pancratistatin, are reported. These syntheses feature a stereo- and regiocontrolled aryl enamide photocyclization to construct a common, advanced intermediate possessing a trans-fused BC substructure. Differential functional group interchange in the C-ring of this phenanthridone core structure allows for the production of the two target natural products in enantiomerically pure form.
Related Papers
- → Recent developments in enantioselective iron-catalyzed transformations(2019)58 cited
- → Alternative Synthetic Strategies for Enantioselective Construction of Halogenated Chiral Carbon Centers(2010)37 cited
- → Methods of Asymmetric Synthesis—Enantioselective Catalytic Hydrogenation(1971)142 cited
- → Chiral B(III) Lewis Acids(2000)19 cited
- → Unactivated Alkenes(2009)3 cited