Synthesis and Absolute Stereochemistry of Roseophilin
Journal of the American Chemical Society2001Vol. 123(35), pp. 8509–8514
Citations Over TimeTop 10% of 2001 papers
Abstract
The enantiospecific total synthesis of natural roseophilin has been completed in 7.0% overall yield over 15 steps by means of an asymmetric cyclopentannelation. This establishes the absolute configuration of the natural product as 22R,23R. Cyclopentenone (+)-12 was prepared in 78% yield and 86% ee in the key step.
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