Internal Derivatization of Oligonucleotides with Selenium for X-ray Crystallography Using MAD
Journal of the American Chemical Society2001Vol. 124(1), pp. 24–25
Citations Over TimeTop 25% of 2001 papers
Abstract
We have developed a route for the synthesis of 2'-selenium uridine analogues and oligonucleotides containing selenium labels, and have demonstrated for the first time a new strategy to covalently derivatize nucleotides with selenium for phase and structure determination in X-ray crystallography.
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