Bio-Barcodes Based on Oligonucleotide-Modified Nanoparticles
Journal of the American Chemical Society2002Vol. 124(15), pp. 3820–3821
Citations Over TimeTop 10% of 2002 papers
Abstract
By utilizing oligonucleotide-modified Au nanoparticles encoded with sequences that act as biobarcodes, one can screen for multiple target polyvalent proteins simultaneously in one solution. This novel concept was demonstrated with two types of detection formats, a homogeneous assay and one based on oligonucleotide microarrays. With such an approach, one can prepare an extraordinarily large number of barcodes from synthetically accessible oligonucleotides (e.g., a 12-mer sequence offers 4(12) possible barcodes).
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