Stereoselectivity of the Benzannulation Reaction: Efficient Central-to-Axial Chirality Transfer
Journal of the American Chemical Society2002Vol. 124(23), pp. 6512–6513
Citations Over TimeTop 10% of 2002 papers
Abstract
High diastereoselectivity is observed in the preparation of configurationally stable allocolchicinoids 5 from Fischer carbene complexes 4 and 1-pentyne. The analogous reaction of complexes 8 gives 9 with moderate diastereoselectivity for the opposite atropisomer and this selectivity can be taken to high levels under thermodynamic conditions.
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