Peptide Dendrimers Based on Polyproline Helices
Journal of the American Chemical Society2002Vol. 124(30), pp. 8876–8883
Citations Over TimeTop 1% of 2002 papers
Laia Crespo, Glòria Sanclimens, Beatriz Montaner, Ricardo Pérez‐Tomás, Míriam Royo, Miquel Pons, Fernando Alberício, Ernest Giralt
Abstract
We present a new family of peptide dendrimers based on polyproline helices and cis-4-amino-L-proline as a branching unit. Dendrimers were synthesized by a convergent solid-phase peptide synthesis approach. The conformational transition between polyproline type I helix and polyproline type II helix was observed by circular dichroism in branched polyproline building blocks with more than 14 proline residues and in the resulting dendrimers. Both linear and dendritic polyprolines were found to be actively internalized by rat kidney cells. Preliminary results show that the antibiotic ciprofloxacin form complexes with branched polyproline chains in 99.5% propanol.
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