Highly Enantioselective Epoxidation of α,β-Unsaturated Esters by Chiral Dioxirane
Journal of the American Chemical Society2002Vol. 124(30), pp. 8792–8793
Citations Over TimeTop 10% of 2002 papers
Abstract
This paper describes a highly enantioselective epoxidation of alpha,beta-unsaturated esters using the fructose-derived ketone 2 as catalyst and Oxone as oxidant. High ee's have been obtained for a number of trans and trisubstituted substrates (82-98% ee). The results described show that it is feasible for dioxiranes to effectively epoxidize electron-deficient olefins with high ee's.
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