A Copper-Catalyzed C−N Bond Formation Involving sp-Hybridized Carbons. A Direct Entry to Chiral Ynamides via N-Alkynylation of Amides
Journal of the American Chemical Society2003Vol. 125(9), pp. 2368–2369
Citations Over TimeTop 1% of 2003 papers
Michael O. Frederick, Jason A. Mulder, Michael R. Tracey, Richard P. Hsung, Jimin Huang, Kimberly C. M. Kurtz, Lu Shen, Christopher J. Douglas
Abstract
A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides.
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